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EU Science Hub

EU Reference Laboratory for alternatives to animal testing (EURL ECVAM)

Welcome to EURL ECVAM! We promote and facilitate the use of non-animal methods in testing and research.

EURL ECVAM is an integral part of the Joint Research Centre (JRC), the science and knowledge service of the European Commission. We are located on the JRC site in Ispra, Italy.


What we do

For over 30 years, the JRC has been working on the Three Rs – the Replacement, Reduction and Refinement of animal experiments. The mandate of EURL ECVAM set out in EU legislation on the protection of animals used for scientific purposes and includes a number of duties:

Our activities

Find out about the validation process, validated test methods, how to submit a test method and much more.

Read our reviews on emerging non-animal models used for research in different disease areas.

Discover our education and training activities targeting secondary schools, universities and professional development.

Advancing alternative approaches through better knowledge sharing. Be part of the Three Rs knowledge community!

Making biological sense of COVID-19 using the Adverse Outcome Pathways (AOP) knowledge management framework.

Find out about our work!

Want to know more?

Check out our FAQs to get a better understanding of who we are and what we do.

Our 'News from EURL ECVAM ' provides updates and highlights of our activities. Why not subscribe to receive it by email!

Open Calls


The 2023 EURL ECVAM Status Report outlines research and development activities, along with initiatives that foster the implementation and utilisation of non-animal methods and approaches in scientific research and regulation.

Contact us


JRC-F3-ENQUIRIESatec [dot] europa [dot] eu
Postal address

Via Enrico Fermi, 2749
21027 Ispra VA