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EU Science Hub

EU Reference Laboratory for alternatives to animal testing (EURL ECVAM)

Welcome to EURL ECVAM! We promote and facilitate the use of non-animal methods in testing and research.

EURL ECVAM is an integral part of the Joint Research Centre (JRC), the science and knowledge service of the European Commission. We are located on the JRC site in Ispra, Italy.

What we do

For over 30 years, the JRC has been working on the Three Rs – the Replacement, Reduction and Refinement of animal experiments. The mandate of EURL ECVAM set out in EU legislation on the protection of animals used for scientific purposes and includes a number of duties:

Our activities

Method validation

Find out about the validation process, validated test methods, how to submit a test method and much more.

Biomedical research

Read our reviews on emerging non-animal models used for research in different disease areas.

Three Rs in education

Discover our education and training activities targeting secondary schools, universities and professional development.

Knowledge sharing

Advancing alternative approaches through better knowledge sharing. Be part of the Three Rs knowledge community!

CIAO project

Making biological sense of COVID-19 using the Adverse Outcome Pathways (AOP) knowledge management framework.

Find out about our work!

Want to know more?


Check out our FAQs to get a better understanding of who we are and what we do.


Our 'News from EURL ECVAM ' provides updates and highlights of our activities. Why not subscribe to receive it by email!

Open Calls

Contact us


JRC-F3-ENQUIRIESatec [dot] europa [dot] eu
Poštni naslov
Via Enrico Fermi, 2749, 21027 Ispra VA, Italy