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EU Reference Laboratory for alternatives to animal testing

Welcome to the European Union Reference Laboratory for alternatives to animal testing - EURL ECVAM!

EURL ECVAM is an integral part of the Joint Research Centre (JRC), the science and knowledge service of the European Commission and is located at the JRC site in Ispra, Italy.


The mandate of EURL ECVAM is specified in EU legislation on the protection of animals used for scientific purposes and includes a number of duties to advance the Replacement, Reduction and Refinement (the Three Rs) of animal procedures.

The current activities of EURL ECVAM build on over 30 years of JRC support to the Three Rs and include:

  • conducting research and collaborating in EU and international research initiatives;
  • coordination and undertaking of validation studies of alternative methods for the safety assessment of chemicals;
  • dissemination of information and sharing of knowledge across disciplines and sectors;
  • and promotion of alternative methods and the Three Rs in an international context.

On this website we present our activities under the headings of Alternative Methods to Toxicity Testing and Knowledge Sharing on the Three Rs.

You can also check out our recent EURL ECVAM Status Report, our latest EURL ECVAM News and our Frequently Asked Questions.

If you don't find what you're looking for then please send us an enquiry and we'll do our best to provide you with the information you need.