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More than 13,000 abstracts were screened to review and catalogue different alternative methods in the field of neurodegenerative diseases developed or used between 2013 and 2018.

The resulting inventory includes 567 models, ranging from biochemical and computational approaches to different types of cell cultures and procedures using ex vivo human material.

Knowledge base

An important outcome of this study is a highly curated knowledge base containing detailed descriptions of 568 non-animal models used for neurodegenerative disease research.

It is easily downloadable as a spreadsheet file from the EURL ECVAM collection in the JRC Data Catalogue.

Tecnical report

A Technical Report provides an in-depth analysis of the models identified and a description of the review methodology employed.

Executive summary

An Executive Summary gives an overview of the study.


Download the leaflet:

Advanced Non-Animal Models in Biomedical Research - Neurodegenerative Diseases
(563.96 KB - PDF)
One important obstacle to progress in the field of neurodegenerative diseases is the heavy reliance on animal models which are failing to capture key features of human biology and disease
© Krylenko - Adobe Stock

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