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Microarray expression studies on CRISPR/CAS9 modified HL-60 cell line treated with small chemical compounds thet inhibit EIF6 gene. A cellular model for Shwachman-Diamond

The aim of the project is to develop a cheap and simple cellular model for the Shwachman-Diamond Syndrome by the use of the well-known HL-60 cell line. The syndrome is a rare autosomal recessive disease. The HL-60 cell line is easy to manipulate and maintaine in culture.

Lead institution

University of Insubria – Department of Medicine and Surgery

Institution

  • National Research Council – Institute for Genetic and Biomedical Research (IT)