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In a detailed analysis of the scientific literature, over 21,000 abstracts (11,636 non-cancer and 9,421 cancer) were scanned for relevant non-animal models of respiratory disease (e.g. asthma, COPD).

From this, a total of 284 publications were identified as the most representative and innovative models according to a set of inclusion/exclusion criteria. In vitro cell and tissue cultures, human ex vivo, in silico approaches were chiefly considered.

Knowledge base

The result is a unique highly curated knowledge base containing detailed descriptions of non-animal models being used for respiratory disease research, including information on their applications and biological relevance.

It is freely available in an easy-to-use spreadsheet format from the EURL ECVAM Collection in the JRC Data Catalogue.

Technical report

A technical report is also available with an analysis of the models and methods identified to describe the state-of-the-art from different perspectives, including the most prevalent model types, typical contexts of use and emerging trends.

A description of the review methodology used is also provided.

Executive summary

An executive summary has been produced for non-technical readers interested in how they can benefit from this study.


2. ÚNORA 2022
Advanced Non-animal Models in Biomedical Research: Respiratory Tract Diseases
(557.36 KB - PDF)