In a detailed analysis of the scientific literature, over 21,000 abstracts (11,636 non-cancer and 9,421 cancer) were scanned for relevant non-animal models of respiratory disease (e.g. asthma, COPD).
From this, a total of 284 publications were identified as the most representative and innovative models according to a set of inclusion/exclusion criteria. In vitro cell and tissue cultures, human ex vivo, in silico approaches were chiefly considered.
The result is a unique highly curated knowledge base containing detailed descriptions of non-animal models being used for respiratory disease research, including information on their applications and biological relevance.
It is freely available in an easy-to-use spreadsheet format from the EURL ECVAM Collection in the JRC Data Catalogue.
A technical report is also available with an analysis of the models and methods identified to describe the state-of-the-art from different perspectives, including the most prevalent model types, typical contexts of use and emerging trends.
A description of the review methodology used is also provided.
An executive summary has been produced for non-technical readers interested in how they can benefit from this study.
A new JRC study describes almost 300 non-animal models used for research on respiratory diseases and the development of new drugs and therapies...